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It is recommended setmelanotide for treating obesity and controlling hunger caused by pro-opiomelanocortin deficiency, including proprotein convertase subtilisin/kexin type 1 or leptin receptor ...
NICE
NICE
Pro-opiomelanocortin (POMC) and leptin receptor (LEPR) deficiencies are rare genetic disorders of obesity. These genes are involved in signalling through the melanocortin‑4 receptor (MC4R) neuroendocrine system in the hypothalamus. This system regulates hunger, satiety (a feeling of fullness) and energy expenditure. Setmelanotide (Imcivree, Rhythm Pharmaceuticals) has a marketing authorisation for the 'treatment of obesity and the control of hunger associated with genetically confirmed ...
ver más ... 2022It is recommended placental growth factor (PLGF)-based tests, used with standard clinical assessment to help decide on care (to help rule in or rule out pre-eclampsia) for people with suspected ...
NICE
NICE
Pre-eclampsia is a potentially serious complication of pregnancy, thought to be related to problems with the development of the placenta. Pre-eclampsia is characterised by high blood pressure (hypertension) and proteinuria, which is when the kidneys leak protein into the urine. If pre-eclampsia is not diagnosed and closely monitored, it can lead to potentially life-threatening complications including eclampsia, HELLP syndrome (haemolysis, elevated liver enzymes and low platelets), disseminated ...
ver más ... 2022It is not recommended vertebral body tethering for idiopathic scoliosis in children and young people, only in the context of research
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NICE
Scoliosis is a 3‑dimensional spinal deformity. It causes the bones of the spine to twist or rotate so that the spine curves sideways. In many cases, idiopathic scoliosis is mild and does not need treatment other than close monitoring and physical therapy. For moderate and severe scoliosis, treatment may progress through casting and bracing to spinal surgery. Vertebral body tethering is a nonfusion spinal treatment for idiopathic scoliosis. The aim is to preserve the flexibility of the spine ...
ver más ... 2022It is not recommended aortic remodelling hybrid stent insertion during surgical repair of an acute type A aortic dissection in affected patients
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NICE
An aortic dissection is a serious condition in which a tear occurs in the inner layer of the aorta. Blood flows through the tear and into the wall of the aorta. This forces the inner and middle layers of the aorta to split apart (dissect), creating 2 passages (a true lumen and a false lumen). As more blood flows into the new false lumen the dissection extends along the aorta. This can lead to aortic rupture or decreased blood flow (ischaemia or malperfusion) to organs. Evidence on the safety ...
ver más ... 2022Bioresorbable stent implantation is not recommended to treat coronary artery disease in affected patients, only in the context of research
NICE
NICE
Coronary artery stenosis is usually due to atherosclerotic plaque deposition. This reduces blood flow to the heart muscle and is usually progressive. Symptoms of coronary artery disease usually include angina (chest pain that is exacerbated by exertion). A critical reduction in blood supply to the heart can lead to a heart attack or death. Evidence on the safety of bioresorbable stents has shown an increased risk of serious long-term complications. This includes an increased risk of heart ...
ver más ... 2022