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NICE

NICE

People may have different limb lengths caused by trauma or infection or, more rarely, hypoplasia or dysplasia (congenital conditions such as achondroplasia, Ollier's disease, and brachial plexus palsy). The condition can be unilateral or bilateral. Unequal limb lengths can lead to disability and limit functional ability. Intramedullary distraction systems are intramedullary devices that are similar to intramedullary nails used for managing fractures. Once inserted and fixed, they can be ...

NICE

NICE

Metachromatic leukodystrophy is a genetic condition that affects the central nervous system. It has a significant effect on the quality of life of children with the condition, and their families and carers. It progresses rapidly, with loss of mobility and cognitive function, and causes early death. Treatment options are limited to managing symptoms and supportive care. Clinical evidence suggests that the gene therapy atidarsagene autotemcel improves mobility and cognitive function and could ...

NICE

NICE

This procedure involves removing a gastrointestinal stromal tumour using an endoscope and fórceps, it uses a full thickness resection device, which allows endoscopic resection with a single step, clip and cut technique. . The aim is to remove the tumour without the need for open surgery. The evidence included 1 case series and 2 case reports. Evidence on the safety and efficacy of endoscopic full thickness removal of gastrointestinal stromal tumours of the stomach is inadequate in quality and ...

NICE

NICE

Crohn's disease is a chronic condition that causes inflammation of the gastrointestinal tract. This condition is characterised by recurring periods of active symptoms. At other times health is generally good (remission). Some people are at a higher risk of more frequent flares and relapses that do not respond to standard drug treatment. In the long term, they may be at a higher risk of developing complications and may need surgery.Crohn's disease has no cure. The goal of treatment is to ...

NICE

NICE

MPS 4A is rare and progressive, and has a significant effect on the quality of life of people with the condition, and their families and carers. It causes abnormalities in the joints and bones, respiratory symptoms, pain, fatigue and increasing dependence on a wheelchair. Current treatment options are limited. The company used the same limited economic model structure for the review as for the original guidance. This was despite encouragement to improve the structure to better reflect the ...