Coronavirus (COVID-19): Evidence Collection. Evidence Aid
The COVID-19 pandemic is affecting the provision of surgery for patients.
Recommendations are made at the surgical, staff and patient levels based on multiple reviews.
Recommendations for practices relevant to the conduct of surgery include the use of pre-operative planning, negative pressure ventilation in operating theatres, limited personnel, single-use equipment, designated donning and doffing areas, dedicated COVID-19 theatres and teams and COVID-free facilities, use of regional ...
Coronavirus (COVID-19): Evidence Collection. Evidence Aid
A rapid review was made on the possible use of interleukin 6 blocking agents as treatment for patients with COVID-19.
This review is based on randomized trials with tocilizumab (which shown a decrease in mortality in the first 28 days after treatment and fewer serious adverse events) and sarilumab (with uncertain results).
It´s includes 78 cohort studies with results for 24,087 samples. The studies evaluated 16 antigen and five molecular assays.
The authors concluded that some antigen tests are accurate enough to replace PCR laboratory tests when used in people with COVID-19 symptoms and that antigen tests may be more useful in identifying outbreaks or in selecting people with symptoms for PCR testing. However, the included studies found that people who received a negative antigen test result may still be ...
Information on the immune and bioinformatics identification of the T-cell and B-cell epitopes of the SARS-CoV-2 virus is important for vaccine development.
In this rapid review, the included studies suggest that B and T cell epitopes could be introduced as potential targets in the development of peptide vaccines against SARS-CoV-2. These studies also showed that B and T cells are important weapons of the immune system against pathogens and that the activation of these epitopes plays an ...
Coronavirus (COVID-19): Evidence Collection. Evidence Aid
The COVID-19 pandemic is placing a strain on healthcare resources, services and workers. In this scoping review, the authors searched for studies that investigated the role of community health workers in delivering health or nutrition services in low- or middle-income countries. Community health workers are able to provide services during acute and protracted crises, carrying out critical emergency response activities, although they might suffer from security threats and psychological trauma. ...