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NICE

National Institute for Health and Clinical Excellence (NICE)

Pemetrexed plus carboplatin or cisplatin, with or without pemetrexed maintenance, is the current treatment for: untreated metastatic non-squamous NSCLC (with no EGFR- or ALK‑positive mutations) with a PD‑L1 tumour proportion score between 0% and 49% and metastatic non-squamous EGFR- or ALK-positive NSCLC when targeted therapy is either not an option or has failed. Pembrolizumab monotherapy is the current treatment for untreated metastatic non-squamous NSCLC with a PD‑L1 tumour proportion ...

NICE

National Institute for Health and Clinical Excellence (NICE)

Be aware that an acute cough: is usually self-limiting and gets better within 3 to 4 weeks without antibiotics.Iis most commonly caused by a viral upper respiratory tract infection, such as a cold or flu.Can also be caused by acute bronchitis, a lower respiratory tract infection, which is usually a viral infection but can be bacterial can also have other infective or non-infective causes. For children under 5 with an acute cough and fever, follow the NICE guideline on fever in under 5s: ...

NICE

National Institute for Health and Clinical Excellence (NICE)

NICE is unable to make a recommendation about the use in the NHS of pembrolizumab (Keytruda) for treating recurrent or metastatic squamous cell carcinoma of the head and neck after platinum-based chemotherapy because no evidence submission was received from Merck Sharp & Dohme. We will review this decision if the company decides to make a submission.

NICE

National Institute for Health and Clinical Excellence (NICE)

Palbociclib or ribociclib, taken with an aromatase inhibitor, are usually the first treatments for locally advanced or metastatic, hormone receptor-positive, HER2-negative breast cancer. They are cyclin-dependent kinase 4 and 6 (CDK 4/6) inhibitors, as is abemaciclib. Clinical trial evidence shows that abemaciclib with an aromatase inhibitor increases how long people live without their disease getting worse, compared with an aromatase inhibitor alone. It is not known whether abemaciclib ...

NICE

National Institute for Health and Clinical Excellence (NICE)

Offer patients and carers information and advice on how to care for their wound after discharge. Offer patients and carers information and advice about how to recognise a surgical site infection and who to contact if they are concerned. Use an integrated care pathway for healthcare-associated infections to help communicate this information to both patients and all those involved in their care after discharge. Always inform patients after their operation if they have been given antibiotics.