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Measure albumin-adjusted serum calcium for people with any of the following features, which might indicate primary hyperparathyroidism: symptoms of hypercalcaemia, such as thirst, frequent or ...
NICE
National Institute for Health and Clinical Excellence (NICE)
Consider measuring albumin-adjusted serum calcium for people with chronic non-differentiated symptoms.
ver más ... 2019The evidence on the safety of high-intensity focused ultrasound for symptomatic benign thyroid nodules raises no major safety concerns, however the current evidence on its efficacy is limited in ...
NICE
National Institute for Health and Clinical Excellence (NICE)
Clinicians wishing to do high-intensity focused ultrasound for symptomatic benign thyroid nodules should: Inform the clinical governance leads in their NHS trusts. Ensure that patients understand the procedure's safety and efficacy, as well as any uncertainties about these. Provide them with clear written information to support shared decision making. In addition, the use of NICE's information for the public is recommended. Audit and review clinical outcomes of all patients having ...
ver más ... 2019Naltrexone–bupropion is not recommended within its marketing authorisation for managing overweight and obesity in adults alongside a reduced-calorie diet and increased physical activity.
NICE
National Institute for Health and Clinical Excellence (NICE)
This recommendation is not intended to affect treatment with naltrexone–bupropion that was started in the NHS before this guidance was published. Adults having treatment outside this recommendation may continue without change to the funding arrangements in place for them before this guidance was published, until they and their NHS clinician consider it appropriate to stop. Obesity is very common in England, affecting about 30% of the population. Current management for overweight and obesity ...
ver más ... 2019Current evidence on the safety and efficacy of radially emitting laser fibre treatment of an anal fistula is limited in quantity and quality. Therefore, although there are no major safety concerns, ...
NICE
National Institute for Health and Clinical Excellence (NICE)
Clinicians wishing to do radially emitting laser fibre treatment of an anal fistula should: - Inform the clinical governance leads in their NHS trusts. - Ensure that patients understand the procedure's safety and efficacy, as well as any uncertainties about these. Provide them with clear written information to support shared decision making. In addition, the use of NICE's information for the public is recommended. - Audit and review clinical outcomes of all patients having radially emitting ...
ver más ... 2019Darvadstrocel is not recommended, within its marketing authorisation, for previously treated complex perianal fistulas in adults with non-active or mildly active luminal Crohn's disease.
NICE
National Institute for Health and Clinical Excellence (NICE)
In a single clinical trial comparing remission rates for darvadstrocel and placebo, only an additional 14% of people showed a beneficial effect from darvadstrocel over and above placebo. Reliable follow‑up results are only available for up to 1 year during which time more than 50% of patients who had remission subsequently relapsed in both the darvadstrocel and placebo arms, so it is unclear how long the treatment benefit will last. The additional evidence submitted after consultation did not ...
ver más ... 2019