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Evidencias COVID-19

Cochrane - Revisión sistemática

Quarantine of people exposed to confirmed or suspected cases prevented between 44% and 81% of incident cases and between 31% and 63% of deaths, compared to no measure, according to different scenarios (incident cases: four modeling studies on COVID-19, SARS; mortality: two modeling studies on COVID-19, SARS, low-certainty evidence)

Evidencias COVID-19

CEBM

Data suggest that the harms from using the 4-aminoquinolines, chloroquine and hydroxychloroquine, to treat established covid-19 outweigh their benefits and that there is no benefit in post-exposure prophylaxis

Evidencias COVID-19

CEBM

Patients with severe COVID-19 can develop cytokine release syndrome (“cytokine storm”) and are reported to have high circulating IL-6 concentrations. Tocilizumab is a recombinant humanized anti-human IgG1 monoclonal antibody directed against the interleukin-6 receptor (IL-6R). It has therefore been proposed to be of value in the management of severe COVID-19. Serious and sometimes fatal infections have been reported. The manufacturer therefore recommends that treatment should not be started ...

Prescrire bilan. Towards better patient care: drugs to avoid

Prescrire International

It can cause serious and even life-threatening cardiovas- cular disorders (hypertensive crisis, stroke, and arrhythmias, including atrial fibrillation), as well as ischaemic colitis. These adverse effects are unac- ceptable for drugs indicated for minor, rapidly self-resolving symptoms such as those associated with the common cold

Prescrire bilan. Towards better patient care: drugs to avoid

Prescrire International

It is an heparin derivative authorised for bladder pain syndrome (interstitial cystitis), has uncertain efficacy in relieving the symptoms of this condition and serious adverse effects, including immune-mediated thrombocyto- penia with a consequent risk of arterial thrombosis and pigmentary maculopathy. In the absence of a better alternative, it is more prudent to offer these patients analgesic medication and non-drug measures with a low risk of adverse effects, such as applying heat or cold to ...