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Prescrire bilan. Towards better patient care: drugs to avoid

Prescrire International

The medicinal clays attapulgite (marketed alone or in multi-ingredient preparations), which have been used to treat various intestinal disorders, including diarrhoea, heartburn and gastroesophageal reflux disease. They should be avoided due to the lead they contain. These toxic effects increases with the dose to which patients are exposed.

Prescrire bilan. Towards better patient care: drugs to avoid

Prescrire International

Pentoxyverine, a centrally-acting cough suppressant, can cause cardiac disorders including QT prolongation, and serious allergic reactions

Evidencias COVID-19

IHCAI – DIME. Información seleccionada sobre intervenciones para el tratamiento de COVID-19

A retrospective cohort study was conducted with data from medical centers in China. 29.4% of the total confirmed COVID-19 cases in two cities were studied. Acute inflammation, often seen in critically ill patients with COVID-19, was reported to be the result of type I IFN expression and the subsequent unbalanced IFN response with excessive cytokine production, which could be corrected by IFN administration therapeutic. It is therefore plausible that early administration of IFN in COVID-19 ...

Prescrire bilan. Towards better patient care: drugs to avoid

Prescrire International

Ginkgo biloba, used in cognitive impairment in elderly patients, has no proven efficacy beyond that of a placebo, but can cause haemorrhage, gastrointestinal disorders, skin disorders, seizures and hypersensitivity reactions.

Evidencias COVID-19

IHCAI – DIME. Información seleccionada sobre intervenciones para el tratamiento de COVID-19

Plitidepsin (PTD) is an antineoplastic drug licensed in Australia for the treatment of relapsed or refractory multiple myeloma. It does not have a marketing authorization from the European Medicines Agency. The laboratory responsible for its commercialization ensures that PTD has shown antiviral activity in a human hepatoma cell line infected with the HCoV-229E-GFP virus, a virus similar to SARS-CoV-2. At the moment there is no evidence to make it effective for the treatment of COVID-19 and the ...