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Cochrane Quality and Productivity topics

National Institute for Health and Clinical Excellence (NICE)

"NICE summary of review conclusions

Evidence shows that the use of antibiotic therapy in otherwise healthy children and adults with non-severe salmonella diarrhoea is not effective, is associated with increased adverse events and prolongs the period in which salmonella is microbiologically detected. They should therefore not be offered to otherwise healthy children and adults with non-severe infection.

Not using antibiotic therapy in otherwise healthy children (older than 6 ...

Cochrane Quality and Productivity topics

National Institute for Health and Clinical Excellence (NICE)

"NICE summary of review conclusions

Aspirin cannot be recommended for the primary prevention of cardiovascular events in patients with hypertension because the benefit does not outweigh the harm. The size of the benefit is much greater for secondary prevention, so aspirin is recommended for this indication. Warfarin, glycoprotein IIb/IIIa inhibitors, ticlopidine, and clopidogrel are not recommended for primary prevention of cardiovascular events in patients with hypertension. Further ...

Cochrane Quality and Productivity topics

National Institute for Health and Clinical Excellence (NICE)

"NICE summary of review conclusions

A small number of trials have compared different surgical techniques with inactive and active control treatments for patients with obstructive sleep apnoea/hypopnoea syndrome. The studies do not provide evidence to support the use of surgery because overall significant benefit was not demonstrated. The participants recruited to the studies had mixed levels of apnoea hypopnoea, but tended to have moderate daytime sleepiness, if this was ...

Cochrane Quality and Productivity topics

National Institute for Health and Clinical Excellence (NICE)

"NICE summary of review conclusions

Given the established effectiveness and safety of aminosalicylates (that is, mesalazine or sulfasalazine) for the maintenance of remission in ulcerative colitis, azathioprine and [6-] mercaptopurine cannot be recommended as first-line treatment to prevent the disease from coming back. However, azathioprine may be an effective maintenance treatment for patients who have failed or cannot tolerate mesalazine or sulfasalazine and for patients who need ...

Cochrane Quality and Productivity topics

National Institute for Health and Clinical Excellence (NICE)

"NICE summary of review conclusions

The use of antibiotics in acute laryngitis has not been shown objectively to have any significant clinical benefit that can justify this use in clinical practice. Despite an overall paucity of evidence, treating acute laryngitis with conservative measures in the first instance is appropriate because antibiotics are associated with side effects and an increased incidence of antimicrobial resistance, which is costly and harmful to the population as a ...