National Institute for Health and Clinical Excellence (NICE)
"NICE summary of review conclusions
The use of antihistamines, decongestants or a combination of both in otitis media with effusion (OME) was not found to be of benefit for any short or long-term outcomes including resolution of the fluid, hearing problems, or the necessity of additional referral to specialists. Further, using these medications causes side effects, such as gastrointestinal upset, irritability, drowsiness or dizziness in approximately 10% of patients. Therefore, ...
National Institute for Health and Clinical Excellence (NICE)
"NICE summary of review conclusions
Evidence shows that the harms of using a combination of aminoglycoside antibiotic together with narrow-spectrum beta-lactam antibiotic for the empirical treatment of sepsis may outweigh the benefits of using a broad-spectrum beta-lactam alone.
For the empirical treatment of sepsis, broad-spectrum beta-lactam monotherapy should be used; beta-lactam–aminoglycoside combination therapy does not offer an advantage over beta-lactam ...
National Institute for Health and Clinical Excellence (NICE)
"NICE summary of review conclusions
Evidence shows that a course of low-dose corticosteroids lasting for 5 day or longer leads to better outcomes for patients with septic shock. However, shorter courses of high-dose corticosteroids are not effective and should not be used for treating severe sepsis and septic shock.
Although overall corticosteroids did not change 28-day mortality, there was significant heterogeneity between trials. Treatment with a long course (5 days or ...
National Institute for Health and Clinical Excellence (NICE)
"NICE summary of review conclusions
Breathing training, walking aids, neuroelectrical muscle stimulation and chest wall vibration appear to be effective non-pharmacological interventions for relieving breathlessness in the advanced stages of some diseases.
The routine use of acupuncture or acupressure; distractive auditory stimuli (music); relaxation; fans; counselling and support programmes with or without relaxation and breathing training; case management; and ...
National Institute for Health and Clinical Excellence (NICE)
"NICE summary of review conclusions
Evidence shows that joint lavage, used alone, without debridement, for patients with knee osteoarthritis is not effective and should not be used.
Stopping joint lavage alone in patients with osteoarthritis of the knee is likely to improve quality of patient care and result in productivity savings by avoiding an intervention with no proven benefit and unknown potential for serious side effects.