The benefit of anticoagulation shows a positive gradient in relation to treatment time.
The possible excess risk of major bleeding events associated with anticoagulation is still imprecise due to the low event rate.
The effect of anticoagulation on disease progression in patients with milder forms of COVID-19 is not known. The available data also do not allow us to know the effects of different anticoagulants and therapeutic regimens on the clinical outcomes of the disease.
Coronavirus (COVID-19): Evidence Collection. Evidence Aid
Azithromycin has been suggested as possible treatment for COVID-19 patients. In this rapid review, the authors searched for in vivo and in vitro studies assessing the safety and effectiveness of azithromycin for treating COVID-19 patients. They restricted their searches to articles published from 2019 onwards, but did not restrict by language of publication and did the search on 16 April 2020. They included two in vitro studies and one in vivo study, which were all published as pre-prints. At ...
Coronavirus (COVID-19): Evidence Collection. Evidence Aid
In this rapid review, the authors searched for studies of the psychological impact on healthcare staff working with patients during an outbreak of an emerging virus in any clinical setting. They did not restrict their searches by language of publication and did the search in late March 2020. They included 59 studies, covering studies on SARS (37 studies), MERS (7), Ebola virus disease (3), COVID-19 (8) and influenza A virus subtypes H1N1 (3) and H7N9 (1). At the time of the review, the included ...
Coronavirus (COVID-19): Evidence Collection. Evidence Aid
Infection prevention and control interventions are especially important during the COVID-19 pandemic. In this rapid review, the authors searched for studies about the persistence of human and veterinary coronaviruses on inanimate surfaces and their inactivation with biocidal agents. They restricted their search to the MEDLINE database did the search on 28 January 2020. They included 22 studies. At the time of this review, the included studies showed that coronaviruses can remain infectious on ...
-In these studies, this modality of MV was associated with better oxygenation (in terms of before-after difference in PaO2 / FiO2) and a lower frequency of arrhythmias.
-This measure would simultaneously demand greater nursing care, given the excess risk of pressure ulcers and endotracheal tube obstructions associated with this type of MV.
-There are no studies that specifically evaluate the impact of this type of MV in patients with acute respiratory failure associated with COVID-19.