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Statins for the treatment of dementia
Cochrane Quality and Productivity topics
National Institute for Health and Clinical Excellence (NICE)
"NICE summary of review conclusions
At present, evidence to recommend statins for the treatment of dementia is insufficient. Analysis from the studies available, including one large randomised control trial indicate that statins have no clear benefit on cognitive performance as measured by the ADAS-Cog or MMSE cognitive assessment scales.
Stopping or reducing the use of stains solely for the treatment of dementia outside of clinical trials is likely to lead to improved ...
Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders
Cochrane Quality and Productivity topics
National Institute for Health and Clinical Excellence (NICE)
"NICE summary of review conclusions
Selective serotonin reuptake inhibitors show no evidence of benefit in children with autistic spectrum disorders, but evidence of harm is emerging. Evidence of the effectiveness of selective serotonin reuptake inhibitors for autism in adults is also limited.
Reducing or stopping the use of selective serotonin reuptake inhibitors to manage autism in children outside of research or on a specific case-by-case basis may improve clinical ...
Stavudine or zidovudine in three-drug combination therapy for initial treatment of HIV infection in antiretroviral-naive individuals
Cochrane Quality and Productivity topics
National Institute for Health and Clinical Excellence (NICE)
"NICE summary of review conclusions
Overall the systematic review showed no critical difference between stavudine and zidovudine as part of first-line therapy for patients with HIV. Other existing literature reports a more significant side-effect profile with stavudine than zidovudine, and thus stavudine is not recommended as first-line treatment. Future studies and recommendations should focus on specific toxicities and tolerability when comparing these drugs.
Patients ...
Don't routinely order renal Ultrasonography in the Evaluation of the patients with Acute Kidney Injury and low risk of obstruction.
Less Is More Collection - JAMA Network
Licurse A, et al. Arch Intern Med. 2010;170(21):1900-1907
For further information please visit the website of the initiative (link below)
ver más ... 2010Effects of Lowering Homocysteine Levels With B Vitamins on Cardiovascular Disease, Cancer, and Cause-Specific Mortality: Meta-analysis of 8 Randomized Trials Involving 37 485 Individuals
Less Is More Collection - JAMA Network
Clarke R, et al. Arch Intern Med. 2010;170(18):1622-1631.
For further information please visit the website of the initiative (link below)
ver más ... 2010