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It is recommended not to use lenalidomide until the third line in the treatment of patients with advanced multiple myeloma.
Iniciativa MAPAC (Mejorar la Adecuación de la Práctica Asistencial y Clínica)
Hospital de Sant Pau
In patients with advanced multiple myeloma, it is recommended first-line chemotherapy (Vincristine, Carmustine, Melphalan, Cyclophosphamide and prednisone alternating with Vincristine, Carmustine, Doxorubicin, Dexamethasone, VBCMP / VBAD) and two cycles of bortezomib, and the second-line treatment after first relapse, it is recommended again bortezomib. The Lenalidomide only manage third line after the second relapse. It also states that in responding patients after 12 cycles of lenalidomide ...
ver más ... 2011It is recommend using only one to three lines of treatment in patients with advanced multiple myeloma.
Iniciativa MAPAC (Mejorar la Adecuación de la Práctica Asistencial y Clínica)
Hospital de Sant Pau
In patients with advanced multiple myeloma, it is recommended first-line chemotherapy (Vincristine, Carmustine, Melphalan, Cyclophosphamide and prednisone alternating with Vincristine, Carmustine, Doxorubicin, Dexamethasone, VBCMP / VBAD) and two cycles of bortezomib. In the second-line treatment after first relapse, it is recommended again bortezomib, and the next relapse, in third-line therapy, administered lenalidomide.
ver más ... 2011It is not recommended to use more than three lines of treatment in patients with advanced colorectal cancer.
Iniciativa MAPAC (Mejorar la Adecuación de la Práctica Asistencial y Clínica)
Hospital de Sant Pau
In the treatment of patients with advanced colorectal cancer, it is not recommended to use more than two combinations of chemotherapy and two biological agents, distributed between one and three lines of treatment. A fourth line should be administered exceptionally. The oncologist should evaluate the clinical circumstances and preferences of each patient when establishing the best therapeutic sequence.
ver más ... 2011It is recommended to switch the administration of paracetamol/acetaminophen to orally from intravenously as soon as possible in inpatients, in order to reduce the time of intravenous administration.
Iniciativa MAPAC (Mejorar la Adecuación de la Práctica Asistencial y Clínica)
Hospital de Sant Pau
It is recommend to use oral instead of intravenous administration of paracetamol/acetaminophen as soon as the patient starts eating or taking medications, unless there is a contraindication, which should be stated explicitly in the respective medical record.
ver más ... 2011There is no evidence to suggest that splint immobilization is inferior to cast immobilization for functional recovery without increasing complications of pediatric buckle wrist fractures in children ...
Choosing Wisely UK
Royal College of Emergency Medicine
Children with small fractures on one side of the wrist, ‘buckle fractures’ do not usually need a plaster cast. They can be treated with a removable splint and written information. There is usually no need to put a plaster cast on, or follow these children up in fracture clinic as they will get better just as quickly without this. No good trials but all trials have no refracture complications. No evidence to suggest that futura splint is inferior to plaster cast immobilisation it is ...
ver más ... 2010