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Less Is More Collection - JAMA Network

JAMA Network

In this systematic review and meta-analysis of 11 randomized clinical trials, rapid viral testing was not associated with reduced antibiotic use, ED length of stay, and the rate of ED return visits or of hospitalization. However, rapid viral testing was associated with moderately increased influenza antiviral use (absolute risk difference 1%) and decreased use of chest radiography and blood tests (absolute risk difference, 3%-4% each). Preferred Reporting Items for Systematic Reviews and ...

NICE

NICE

Endoscopic sleeve gastroplasty is a minimally invasive transoral endoscopic procedure that reduces the volume of the stomach and may delay gastric emptying. It creates a sensation of fullness and reduces the amount of food that can be eaten at one time. Evidence on safety shows this procedure is safe in the short and long term. Evidence on efficacy shows that, when combined with lifestyle changes, people with a body mass index (BMI) over 30 kg/m2 who have the procedure lose weight. So, it can ...

NICE

NICE

In the management of suspected sepsis in acute hospital settings in patients over 16 years of age at risk of severe illness or death, it is recommended that a physician with basic competencies in acute illness evaluate the patient, as well as perform a blood test. which includes: blood gases, including measurement of glucose and lactate, blood culture, complete blood count, C-reactive protein, urea and electrolytes, creatinine, liver function tests and a coagulation study. It is also ...

Less Is More Collection - JAMA Network

JAMA Network

Single case study that describes the situation of a woman with adverse effects from taking digoxin. Symptoms and signs were chest pain, nausea, anorexia and fatigue.

NICE

NICE

Evidence from clinical trials suggests that sebelipase alfa increases the life expectancy of patients with Wolman's disease (rapidly progressive lysosomal acid lipase deficiency), a rare genetic condition that occurs in infants and children under 2 years of age. It causes a buildup of fat in the cells of the liver, heart, blood vessels and digestive system. Without treatment, the infant or child will not survive. With sebelipase alfa treatment, it is unclear how much longer these patients will ...