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NICE

NICE

Progressive familial intrahepatic cholestasis is a rare and serious genetic condition that reduces or stops the flow of bile acids from the liver. This can cause severe itching, poor growth, and liver damage. Progressive familial intrahepatic cholestasis severely affects the quality of life of people with the condition and their families and caregivers. It is fatal if left untreated. There is evidence that in progressive familial intrahepatic cholestasis types 1 and 2, odevixibat reduces blood ...

NICE

NICE

Exceptional medical circumstances include the occurrence of serious side effects (for example, upper gastrointestinal bleeding from an antidepressant, respiratory depression from an opioid or severe ataxia from a gabapentinoid). In these circumstances, consider: -scheduling more frequent reviews -short-term use of medicines to treat the physical symptoms of withdrawal (for example, abdominal cramps and diarrhoea during withdrawal of an opioid). Medicines associated with dependence include ...

NICE

NICE

Subglottic or tracheal stenosis is a narrowing of the airways. It can be congenital, traumatic, or more commonly iatrogenic after prolonged endotracheal intubation. The aim of endoscopic balloon dilation is to dilate airway strictures with minimal mucosal trauma by applying pressure to an area of ​​stricture. Endoscopic balloon dilation is not recommended for subglottic or tracheal stenosis in adults, but it is recommended in infants, children, and young people. The evidence included 1 ...

NICE

NICE

EarlyCDT lung is a blood test to assess the risk of malignancy of solid lung nodules found by CT scan or chest X-ray. It measures the presence of autoantibodies against a panel of 7 acute ones associated with lung cancer. EarlyCDT Lung is used to assess the risk of lung cancer in solid lung nodules. Accurate risk assessment can prevent delayed treatment of malignant nodules or unnecessary biopsies of benign nodules. However, the evidence on how well EarlyCDT Lung works is limited and ...

NICE

NICE

People may have different limb lengths because of trauma or infection (acquired) or, because of hypoplasia or dysplasia of the femur or tibial (congenital). Unequal leg length can cause a limp, limit functional ability and have effect on other joints. This procedure involves surgically inserting a metal lengthening device in the shorter leg. The aim is to lengthen the bone in a controlled manner. This procedure should only be used with special arrangements for clinical governance, consent, and ...