National Institute for Health and Clinical Excellence (NICE)
Explain to people that most tests for Lyme disease assess for the presence of antibodies and that the accuracy of tests may be reduced if:
- testing is carried out too early (before antibodies have developed)
- the person has reduced immunity, for example, people on immunosuppressant treatments, which might affect the development of antibodies.
Advise people that tests from non-UKAS laboratories may not have been fully evaluated to diagnose Lyme disease.
Explain to people that:
- the symptoms ...
National Institute for Health and Clinical Excellence (NICE)
Use a combination of clinical presentation and laboratory testing to guide diagnosis and treatment in people without erythema migrans. Do not rule out diagnosis if tests are negative but there is high clinical suspicion of Lyme disease.
If there is a clinical suspicion of Lyme disease in people without erythema migrans:
- offer an enzyme-linked immunosorbent assay (ELISA) test for Lyme disease and
- consider starting treatment with antibiotics while waiting for the results if there is a high ...
National Institute for Health and Clinical Excellence (NICE)
- increases in size and may sometimes have a central clearing
- is not usually itchy, hot or painful
- usually becomes visible from 1 to 4 weeks (but can appear from 3 days to 3 months) after a tick bite and lasts for several weeks
- is usually at the site of a tick bite.
Be aware that a rash, which is not erythema migrans, can develop as a reaction to a tick bite that:
- usually develops and recedes during 48 hours from the time of the tick bite
- is more likely than erythema migrans to be ...
National Institute for Health and Clinical Excellence (NICE)
- the bacteria that cause Lyme disease are transmitted by the bite of an infected tick
- ticks are mainly found in grassy and wooded areas, including urban gardens and parks
- tick bites may not always be noticed
- infected ticks are found throughout the UK and Ireland, and although some areas appear to have a higher prevalence of infected ticks, prevalence data are incomplete
- particularly high-risk areas are the South of England and Scottish Highlands but infection can occur in many areas
- ...