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NICE

National Institute for Health and Clinical Excellence (NICE)

The procedure should only be done by surgeons experienced in cartilage surgery and with specific training in mosaicplasty for knee cartilage defects. Clinicians should enter data from all patients having the procedure onto the ICRS Patient Registry.

NICE

National Institute for Health and Clinical Excellence (NICE)

Clinicians wishing to do low-intensity pulsed ultrasound to promote healing of delayed-union and non-union fractures should: Inform the clinical governance leads in their NHS trusts. Ensure that patients understand the uncertainty about the procedure's efficacy and provide them with clear written information to support shared decision-making. In addition, the use of NICE's information for the public is recommended. Audit and review clinical outcomes of all patients having low-intensity pulsed ...

NICE

National Institute for Health and Clinical Excellence (NICE)

Current treatment options for chronic hepatitis C depend on genotype, cirrhosis status and treatment history. Glecaprevir–pibrentasvir is suitable for all genotypes and has a shorter treatment duration than most other direct-acting antiviral treatments. Clinical trials show that glecaprevir–pibrentasvir is effective for treating chronic hepatitis C across all genotypes. There was only 1 trial directly comparing glecaprevir–pibrentasvir with other direct-acting antiviral regimens, but ...

NICE

National Institute for Health and Clinical Excellence (NICE)

It is recommended that the decision to treat and prescribing decisions are made by multidisciplinary teams in the operational delivery networks put in place by NHS England, to prioritise treatment for people with the highest unmet clinical need. These recommendations are not intended to affect treatment with sofosbuvir–velpatasvir–voxilaprevir that was started in the NHS before this guidance was published. People having treatment outside these recommendations may continue without change to ...

NICE

National Institute for Health and Clinical Excellence (NICE)

The current evidence on efficacy is very limited in quantity and quality. Therefore, this procedure should only be used in the context of research. Further research should include details of patient selection, fracture site, and risk factors and comorbidities that delay fracture healing.