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NICE

National Institute for Health and Clinical Excellence (NICE)

If patients and their clinicians consider golimumab to be one of a range of suitable treatments, including adalimumab, etanercept and certolizumab pegol, the least expensive (taking into account administration costs and patient access schemes) should be chosen. Assess the response to golimumab 12 weeks after the start of treatment. Continue treatment only if there is clear evidence of response, defined as: a reduction in the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score to ...

NICE

National Institute for Health and Clinical Excellence (NICE)

Stop brodalumab at 12 weeks if the psoriasis has not responded adequately, defined as: a 75% reduction in the PASI score (PASI 75) from when treatment started or a 50% reduction in the PASI score (PASI 50) and a 5‑point reduction in DLQI from when treatment started. When using the PASI, healthcare professionals should take into account skin colour and how this could affect the PASI score, and make the clinical adjustments they consider appropriate. When using the DLQI, healthcare ...

NICE

National Institute for Health and Clinical Excellence (NICE)

Be aware that: - the bacteria that cause Lyme disease are transmitted by the bite of an infected tick - ticks are mainly found in grassy and wooded areas, including urban gardens and parks - tick bites may not always be noticed - infected ticks are found throughout the UK and Ireland, and although some areas appear to have a higher prevalence of infected ticks, prevalence data are incomplete - particularly high-risk areas are the South of England and Scottish Highlands but infection can occur ...

NICE

National Institute for Health and Clinical Excellence (NICE)

Be aware that: - acute sore throat (including pharyngitis and tonsillitis) is self‑limiting and often triggered by a viral infection of the upper respiratory tract - symptoms can last for around 1 week, but most people will get better within this time without antibiotics, regardless of cause (bacteria or virus). Use FeverPAIN or Centor criteria to identify people who are more likely to benefit from an antibiotic. Give advice about: - the usual course of acute sore throat (can last around 1 ...

NICE

National Institute for Health and Clinical Excellence (NICE)

Cost modelling is uncertain because of the limited clinical-effectiveness evidence. Using Neuropad instead of 10 g monofilament testing would likely increase costs because Neuropad has a lower specificity for detecting diabetic peripheral neuropathy. Further research is needed on the benefits and consequences of detecting preclinical diabetic peripheral neuropathy.