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NICE

NICE

Evidence on the safety and efficacy of radiofrequency ablation for palliation of painful spinal metastases is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Clinicians wanting to do radiofrequency ablation for palliation of painful spinal metastases should: - Inform the clinical governance leads in their healthcare organisation. - Give people (and their families and carers as ...

NICE

NICE

AADC deficiency is a rare genetic disorder that causes a wide range of debilitating symptoms. Normal motor development in young children (such as head control, sitting and walking with help) is particularly affected.Severe AADC deficiency is associated with a high risk of death in childhood. It also has a substantial effect on the quality of life of the person with the condition, and their family and carers. The evidence is clinical, because the results of the studies are uncertain because ...

NICE

NICE

Evidence-based recommendations on radiofrequency ablation as an adjunct to balloon kyphoplasty or percutaneous vertebroplasty for palliation of painful spinal metastases. This involves inserting a needle-like probe containing an electrode into the spinal metastases. This produces an electrical current that aims to relieve pain and other symptoms.

NICE

NICE

This evaluation reviews the evidence for asfotase alfa for treating paediatric‑onset hypophosphatasia (NICE highly specialised technologies guidance 6), including evidence collected as part of the managed access agreement. Paediatric‑onset hypophosphatasia is a rare genetic condition that affects how calcium and phosphorous are deposited in developing bones and teeth. It includes perinatal-, infantile- and juvenile‑onset forms of the disease. There are limited treatment options and it ...

Essencial: Afegint valor a la pràctica clínica [Essencial: Adding value to the clinical practice]

Essencial Salud

In adult women, most uncomplicated acute cystitis is caused by Escherichia coli, which causes more than 75% of infections. Clinical practice guidelines position fosfomycin trometamol (3 g in a single dose) as the treatment of choice in uncomplicated acute cystitis, since the most common uropathogens are sensitive, and it has a narrow spectrum. Alternatively, nitrofurantoin (for five days) could be considered. Treating uncomplicated acute cystitis with fluoroquinolones or amoxicillin/clavulanic ...