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There is uncertainty about the beneficial effect of Tocilizumab as a potential therapy against COVID-19, since it can also carry unknown damage and, therefore, it should be considered as an ...
Evidencias COVID-19
Cochrane Navarra - Sección de Innovación y Organización del SNS-O
- There is currently no well validated effective treatment for COVID-19. - Tocilizumab (TCZ) is authorized in Spain for patients with severe involvement of T-CAR cell-induced cytokine release syndrome (SLC). - There are no clinical trials with results available regarding the use of TCZ in patients with COVID-19. - The study by Xu et al. It presents important limitations in its non-experimental and non-comparative design, so its hypotheses require confirmation. - A retrospective analysis of 66 ...
ver más ... 2020There is uncertain the effect of some drugs to reduce early mortality in critically ill patients with Acute Respiratory Distress Syndrome (ARDS)
Evidencias COVID-19
Coronavirus (COVID-19): Evidence Collection. Evidence Aid
Corticosteroids may reduce all-cause mortality within 3 months and increase the number of ventilator-free days up to day 28. It is uncertain if corticosteroids make any difference to late (later than 3 months) all-cause mortality. Surfactants, N-aceytylcysteine and statins probably make little or no difference to early mortality. Beta-agonists probably slightly increase early mortality. The review did not investigate the effects of nitric oxide, inhaled prostacyclins, partial liquid ...
ver más ... 2020It is uncertain whether daily interruption of sedation alters clinical outcomes in adults with mechanical ventilation
Evidencias COVID-19
Coronavirus (COVID-19): Evidence Collection. Evidence Aid
Some patients with COVID-19 will develop respiratory failure and need help with their breathing. This might be provided by mechanical ventilation (MV) in an intensive care unit (ICU). This requires the patient to be sedated, which can cause complications. Daily sedation interruption might be used to try to reduce these. In this Cochrane systematic review, the authors searched for randomized trials comparing DSI with other sedation strategies for critically ill adults receiving MV. Although ...
ver más ... 2020Based on the available evidence, the benefits and harms of hand cleaning with ash compared with soap or other materials for reducing the spread of viral or bacterial infections are uncertain.
Evidencias COVID-19
Cochrane - Revisión rápida
Handwashing is important to reduce the spread and transmission of infectious disease. Ash, the residue from stoves and fires, is a material used for cleaning hands in settings where soap is not widely available. We identified 14 studies that assessed ash for hand cleaning. Only one small study directly compared people chosen at random to use ash or soap or other materials (randomised studies produce the best evidence). Our certainty (confidence) in the evidence was limited because we found few ...
ver más ... 2020There is no evidence on the negative impact of these measures on the physical health, cognitive and emotional state and social and supportive relationships of older people, nor on how to prevent or ...
Evidencias COVID-19
Fundació Salut i Envelliment-UAB - Centro Cochrane Iberoamericano
Older people are a particularly vulnerable group with a poor prognosis in relation to COVID-19, and they are a priority population for confinement and social distancing initiatives to avoid the spread of SARS-CoV-2. There is evidence that provides information with very low certainty that older people with good self-perception of aging could be more resilient in the face of the suffering situation (negative stress) that confinement and the current pandemic entails. Women suffer more loneliness ...
ver más ... 2020