Dysphagia is a common complication after acute stroke occurring in 51%-55% of cases. Strokes can cause dysphagia through damage to any of the brain areas involved in swallowing physiology, including the cerebral hemispheres, the cerebellum or the brain stem. The diagnosis of dysphagia is important as it can lead to complications such as pneumonia. For those patients who do not recover before discharge, a decision should be made whether to provide prolonged NG tube feeding or to place a PEG ...
Opioids are effective for the treatment of pain and dyspnea in dying patients and are recommended as first-line agents by professional guidelines, but dying itself does not automatically require opioid treatment, and many nonpharmacological interventions can increase comfort without involving no medicine. In cases where medication is required, opioid infusions as initial therapy are less effective than opioid boluses.
Based on clinical guideline practices, randomized continuous sequential ...
A systematic review summarizing the efficacy and safety of these agents found no consistent trends in their effects on improving sleep with respect to latency, efficiency, quality, or disruptions.
Studies associate benzodiazepines, benzodiazepine receptor agonists, barbiturates, SGAs, and antihistamines with delirium, cognitive impairment, fall-related injuries, and death, especially in the elderly.
If AII persists despite nonpharmacological interventions, consider prescribing MRAs as a safer ...
Fragility hip fractures are a major public health problem. After one year, less than half of patients have recovered their pre-fracture functional status, and up to 30% of them have died.
One clinical trial randomised 2127 men and women with fragility hip fractures from 115 clinical centres to annual intravenous (IV) infusions of zoledronic acid (started within 90 days of surgical repair) versus placebo. Patients receiving zoledronic acid had a 35% reduction in the risk of new clinical ...
Essencial: Afegint valor a la pràctica clínica [Essencial: Adding value to the clinical practice]
Generalitat de Catalunya
Valproic acid, approved for the treatment of certain types of epilepsy and bipolar disorder, is teratogenic. Babies born to women treated with the drug have an increased risk of neurodevelopmental disorders or congenital malformations.
Clinical practice guidelines, drug agencies, and consensus documents are aligned in the recommendation to avoid prescribing valproate in women with the capacity to conceive, unless the conditions of the pregnancy prevention program are met.
When the woman is ...