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Evidencias COVID-19

Fundación Cardioinfantil

Current evidence does not allow determining the effect on mortality or other important clinical outcomes of the use of interferon-β 1a or 1b. However, it could have some beneficial effect on the rate of hospital admission on day 14 and decrease the time for RT-PCR to become negative. A similar antiviral response has been found after IV or SC use, despite differences in bioavailability (greater for IV). The choice of route of administration would depend on the severity of COVID-19. Quality of ...

Evidencias COVID-19

Facultad de Medicina, Universidad de Antioquia

Regular disclosure of information is suggested (healthy lifestyles, common emotional reactions in epidemics, advice on coping with isolation and quarantine periods, and warning signs that require individualized evaluation or even emergency care). Likewise, it would be appropriate to encourage peer support to foster a sense of connection and allow experiences to be shared. Also, the university can promote spaces for social interaction that are not only focused on academic aspects but also on ...

Evidencias COVID-19

Fundación Cardioinfantil

The viral load detected in SARS-CoV-2 infected individuals with a positive RT-PCR result is independent of the presence or absence of symptoms at the time of sample collection. The relationship between viral load and level of severity of COVID-19, nor the relationship between the viral load identified in asymptomatic carriers and the subsequent period of transmissibility, is not known. Viral load was very similar (although it reached statistical significance) between populations with and ...

Less Is More Collection - JAMA Network

Rastogi R. JAMA Intern Med.

This cohort study found that 78% of adult patients admitted for noncardiovascular diagnoses had at least 1 hypertensive blood pressure measurement, but fewer than 1 in 3 had their medication intensified. More surprisingly, only 8% of hypertensive blood pressure readings prompted medication escalation, and even systolic readings greater than 220 mm Hg were treated less than half the time. Paradoxically, the treatment, defined as administration of an intravenous antihypertensive drug or a new ...

Smarter medicine

Sociedad Suiza de Reumatología

Currently, there is no evidence to support the prescription of opioid analgesics for patients with acute nonspecific low back pain, and only moderate pain relief with opioid analgesics has been shown in patients with chronic low back pain. In addition, there is growing concern about the adverse effects of opioids, including overdoses and deaths. The management of chronic low back pain includes primarily non-pharmacological treatments and, in case of failure, pharmacological treatment with ...