In people with comorbidities who have been receiving treatment with angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs), there may be a lower risk of SARS-CoV-2 infection and the development of severe forms of COVID-19.
Evidence quality: moderate (from observational studies with moderate risk of bias, lack of precision in some outcomes, and lack of consistency in the direction of the association with different outcomes).
Current evidence does not support ...
Modeling studies consistently reported the beneficial effect of simulated quarantine measures. Quarantine of people exposed to confirmed or suspected cases prevented between 44% and 81% of incident cases and between 31% and 63% of deaths.
Very low-certainty evidence suggests that the effect of quarantining travelers from a country with a declared outbreak on reducing incidence and deaths was small.
When the models combined quarantine with other prevention and control measures, including school ...
It is are uncertain whether a higher or lower oxygen target is more beneficial in patients with ARDS receiving mechanical ventilation in an intensive care setting. There was no evidence of a difference between the lower and higher target groups in the mean number of days on ventilation, number of days of catecholamine use, or participants receiving renal replacement therapy.
A single RCT with a total of 205 participants exploring this question was identified, and we rated the risk of bias as ...
Current recommendations on safe physical distancing (one to two meters) are based on outdated evidence. In a systematic review carried out in the context of the covid-19 pandemic, it was observed that the distribution of viral particles is affected by numerous factors such as airflow, ventilation, type of activity, viral load and duration of exposure. The exhibition. In the highest risk situations, a physical distance of more than two meters should be considered and the occupation time ...
Cochrane Portugal - Instituto de saúde baseada na evidência
Health professionals (HCPs) are often at higher risk of contracting infections, in particular from Sars-CoV-2.The results of this study indicate that HCPs constitute a significant proportion of those infected, with a high incidence of contagion in unprotected contacts. However, they present less severe symptoms. The highest risk of infection was found in the context of nasotracheal intubation, in direct contact with patients and/or body fluids. The most significant reduction in risk factors was ...