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NICE

NICE

People with ALK-positive advanced NSCLC who have not had an ALK inhibitor before are usually offered alectinib. If a person's ALK status is not known at diagnosis, crizotinib is offered after chemotherapy. Brigatinib may be offered as an alternative to these treatments. Clinical evidence shows that brigatinib is more effective than crizotinib at delaying disease progression. It suggests that brigatinib extends life more than crizotinib, but this is uncertain. There is no clinical trial ...

NICE

NICE

Trifluridine–tipiracil (Lonsurf, Servier) is indicated as 'monotherapy for the treatment of adult patients with metastatic gastric cancer including adenocarcinoma of the gastroesophageal junction, who have been previously treated with at least 2 prior systemic treatment regimens for advanced disease'. Current treatment for metastatic gastric cancer and gastro-oesophageal junction cancer, for most people who have had 2 treatments, is best supportive care. The clinical evidence suggests that ...

NICE

NICE

Treatment for BRAF V600E mutation-positive metastatic colorectal cancer after previous systemic treatment includes combination chemotherapy, usually FOLFIRI (5‑fluorouracil, folinic acid and irinotecan) followed by trifluridine–tipiracil then best supportive care. Encorafenib plus cetuximab is the first colorectal cancer treatment that targets the BRAF V600E mutation, and could be used second or third line. Clinical trial evidence shows that encorafenib plus cetuximab increases how long ...

Evidencias COVID-19

Coronavirus [COVID-19]: Evidence Collection

Interleukin ‐ 6 blocking agents have been suggested as treatments for COVID-19. In this living Cochrane review, the authors searched for randomized trials of interleukin ‐ 6 blocking agents for COVID-19 patients. They did not restrict their searches by language of publication and did the most recent search on 26 February 2021. They included 9 tocilizumab trials (6428 participants) and two sarilumab trials (880 participants), with one trial testing both drugs. They also identified 39 ...

Evidencias COVID-19

Coronavirus (COVID-19): Evidence Collection. Evidence Aid

Some patients with COVID-19 will become critically ill and require mechanical ventilation in an intensive care unit. One complication of this is ventilator-associated pneumonia. This is an updated Cochrane review showing that chlorhexidine mouthwash or gel probably reduces the incidence of ventilator‐associated pneumonia in critically ill patients, when compared to placebo or usual care. Oral hygiene care including both antiseptics and toothbrushing may be more effective than antiseptics ...