In this Cochrane review, the authors searched for randomized trials testing chloroquine or hydroxychloroquine in COVID-19 patients, people at risk of exposure to SARS-CoV-2 or people exposed to SARS-CoV-2. They included 12 trials (8569 participants) of the treatment of COVID-19 and 2 trials (3346 participants) for preventing COVID‐19 disease in people who have been exposed to SARS‐CoV‐2. They found no trials of chloroquine or hydroxychloroquine for preventing COVID‐19 disease in people ...
The authors searched for studies that assessed the efficacy of adding tocilizumab to standard care for COVID-19 patients.
At the time of the review, the included studies suggest that tocilizumab has the potential to reduce mortality rates and the need for mechanical ventilation in COVID-19 patients with severe disease.
COVID-19 vaccines are becoming available and existing research on how to improve the uptake of vaccination might be useful for policy makers. In this Cochrane review, the authors searched for comparative effectiveness studies to improve uptake of immunizations.
COVID-19 vaccines are becoming available and existing research on how to improve the uptake of vaccination might be useful for policy makers.
In this Cochrane review, the authors searched for comparative effectiveness studies of interventions to improve uptake of a variety of vaccinations among adolescents.
The reviews, covering a range of clinical areas, suggest that healthcare workers may be at increased risk of COVID-19 from aerosol generating procedures (AGPs).Some reviews suggest that measures to reduce these risks include delaying procedures during the pandemic and the use of antimicrobial treatments before and after the procedures.