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NICE

NICE

Evidence on the safety of percutaneous insertion of a closure device to repair a paravalvular leak around a replaced mitral or aortic valve shows that this procedure can cause potentially serious but well-recognised complications. Evidence on its efficacy is limited in quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Clinicians wishing to do percutaneous insertion of a closure device to repair a ...

NICE

NICE

Glaucoma is usually a chronic condition associated with raised intraocular pressure that leads to progressive damage to the optic nerve. Early stages are usually asymptomatic. As the condition progresses, it causes visual impairment and, if untreated, blindness. Repetitive short-pulse transscleral cyclophotocoagulation (commonly known as micropulse transscleral cytophotocoagulation) uses a laser to target the same tissue as conventional cyclodiode laser treatment but it is delivered in pulses ...

NICE

NICE

Givosiran is recommended as an option for treating acute hepatic porphyria (AHP) in adults and young people aged 12 and older, only if: they have clinically confirmed severe recurrent attacks (4 attacks or more within 12 months) and the company provides it according to the commercial arrangement. Acute hepatic porphyria (AHP) is a rare inherited metabolic disorder caused by a deficiency of the enzymes needed to make haem. It is characterised by high levels of porphyrin precursors, including ...

NICE

NICE

Evidence on the safety of melphalan chemosaturation with percutaneous hepatic artery perfusion and hepatic vein isolation for cancer or metastases in the liver shows there are serious, well‑recognised complications. For patients with metastases in the liver from ocular melanoma, there is some evidence of short‑term tumour response. For these patients, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. For patients with ...

NICE

NICE

Evidence on the efficacy of laser lithotripsy for difficult-to-treat bile duct stones is adequate. However, evidence on its long-term safety is limited in quantity. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Clinicians wishing to do laser lithotripsy for difficult-to-treat bile duct stones should: - Inform the clinical governance leads in their healthcare organisation. - Give patients (and their families and ...