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Renin-angiotensin-aldosterone system inhibitors should continue to be administered to at-risk patients diagnosed with COVID-19 infection.
Evidencias COVID-19
Cochrane Portugal - Institute for Evidenced Based Health
The preclinical studies (in animal models) have planted the security management guideline for ISRAA administration in patients with COVID-19. However, according to current evidence, despite the questions about the effect of ISRAA in ECA2 and how these drugs can affect the severity of SARS-CoV-2 infection, it seems justified that this pharmacological group should continue to be administered to patients of stable risk that has been evaluated for what has not been diagnosed with coronavirus. The ...
ver más ... 2020There is uncertainty regarding the use of remdesivir in patients with severe COVID-19 disease in clinical practice
Evidencias COVID-19
Cochrane Portugal - Institute for Evidenced Based Health
A retrospective cohort study, funded by Gilead, looked at 53 patients with confirmed severe SARS-CoV-2 infection, who were given remdesivir (viral RNA polymerase inhibitor) between 01/25/2020 and 3 / 7/2020, in the context of compassionate use for 10 days (first day with a loading dose of 200 mg intravenously and the remaining 9 days with a daily dose of 100 mg). All patients were hospitalized with oxygen saturations of 94% or less in ambient air or with supplemental oxygen support. Of the 53 ...
ver más ... 2020Administration of plasma to convalescent patient has benefits for patients with COVID-19 and severe respiratory failure.
Evidencias COVID-19
Cochrane Portugal - Institute for Evidenced Based Health
After plasma transfusion (which occurred between 10 and 22 days after hospital admission), 4 patients normalized their body temperature within 3 days. There was a reduction in the SOFA score in all patients, an increase in the PAO2 / FIO2 ratio, a reduction and possible negative viral load (within 12 days after the transfusion), and a subsequent increase in the titer of specific antibodies to SARS. -CoV -2, like neutralization. ARDS decreased in 4 patients up to 12 days after the transfusion ...
ver más ... 2020Despite uncertainty associated with the pathogenic characteristics of SARS-CoV-2, measures to isolate cases and contacts and play an important role in bud control.
Evidencias COVID-19
Cochrane Portugal - Institute for Evidenced Based Health
A study that used a mathematical model to predict the effectiveness of measures to isolate cases and contacts in a SARS-CoV-2 outbreak. The authors considered the most current information available on the virus and simulated outbreaks with variable parameters, namely initial cases (5 to 40), basic reproductive number (1.5 to 3.5), the average time between the onset of symptoms and isolation, the proportion of transmission that occurred before the onset of symptoms and the proportion of ...
ver más ... 2020Healthcare professionals should perform effective hand hygiene before direct contact with a patient including aseptic procedures, after direct contact with a patient, immediately after exposure to ...
Evidencias COVID-19
JBI COVID-19 Special Collection
(Grade A) This evidence summary is based on a structured search of the literature and selected evidence-based health care databases. The evidence in this summary comes from: • Evidence-based clinical practice guidelines.1,2 - A scoping review of the literature using a five-stage methodological framework including 21 papers.3
ver más ... 2020