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There is yet no trial evidence of efficacy to use angiotensin-converting enzyme inhibitors, and angiotensin receptor antagonists, for preventing and treating the effects of the coronavirus SARS-CoV-2
Evidencias COVID-19
Oxford COVID-19 Evidence Service.
We do not know whether the supposed benefits of ACE-1 inhibitors or ARBs during an episode of infection with SARS-CoV-2 outweigh the potential harms. It is generally unwise to institute any pharmacological therapy on the basis of an untested mechanistic hypothesis, since unexpected harms may outweigh hoped-for benefits. Until evidence emerges, based on randomized trials or at least data-mining of patients’ records, we suggest that it would be unwise to use either conventional ACE-1 inhibitors ...
ver más ... 2020Current guidance on personal protective equipment (PPE) in the context of COVID-19 does not specifically mention shoe covers.
Evidencias COVID-19
Oxford COVID-19 Evidence Service.
The inclusion of protective shoe covers or footwear as a component of PPE for prevention of acquisition and dissemination of pathogenic microbial agents by healthcare staff derives from documentation of extensive floor contamination with bacterial pathogens. The effectiveness of shoe coverings in diminishing bacterial pathogen acquisition in ICUs has not been clearly demonstrated.[1-3]. COVID-19 is spread by four means: contact (direct or via a fomite); droplet infection (droplets from the ...
ver más ... 2020Effectiveness of quarantine during a viral outbreak relies on the timing and accuracy of the quarantine period, as well as the ability of individuals and health care providers to follow quarantine ...
Evidencias COVID-19
Oxford COVID-19 Evidence Service.
Current evidence to inform quarantine is limited, and COVID-19 infection trends raise critical questions about implementation effectiveness. Recent modelling by Imperial College factored in household quarantine as a key intervention to mitigate against increased infection. Researchers defined a home-based quarantine in response to following identification of a symptomatic case in the household, where all household members remain at home for 14 days. Their assumption suggested household contact ...
ver más ... 2020Several in vitro studies report antiviral activity of chloroquine and hydroxychloroquine against SARS-CoV-2. At present, there is insufficient in Vivo evidence to recommend their use for the current ...
Evidencias COVID-19
Oxford COVID-19 Evidence Service.
In vivo data, although promising, is currently limited to one study with considerable limitations. On the basis of the weak evidence available to date, treatment guidelines have already incorporated the usage of chloroquine/hydroxychloroquine for certain patients with COVID-19. Further research should address the optimal dose and duration of treatment, and explore side effects and long-term outcomes. There is a higher risk of side effects in the presence of renal and liver impairment, and there ...
ver más ... 2020The current evidence for the effectiveness and safety of antiviral therapies for coronavirus is inconclusive and suffers from a lack of well-designed prospective trials or observational studies, ...
Evidencias COVID-19
Oxford COVID-19 Evidence Service.
The results of the included studies proved inconclusive on the effectiveness of antiviral drugs in treating coronavirus infections and prevent any particular treatments from being recommended for use. The existing body of evidence is weighted heavily towards studies of ribavirin which has shown no particular efficacy in treating coronavirus and may, in fact, cause harmful adverse effects particularly the possible development of anemia and altered liver function.
ver más ... 2020