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Based on the non-randomized studies, people with influenza who receive additional steroid treatment may have a greater risk of death compared to those who do not receive steroid treatment
Evidencias COVID-19
Coronavirus (COVID-19): Evidence Collection. Evidence Aid
Corticosteroids are widely used for people with severe influenza, but there is uncertainty about their potential benefits or harms. Corticosteroids have shown evidence of benefit in sepsis and related conditions, which is most likely due to their anti-inflammatory and immunomodulatory properties. Their effects in patients with influenza might indicate their likely effects in people seriously ill with COVID-19. In this Cochrane systematic review, the authors searched for research (randomized ...
ver más ... 2020Drugs such as remdesivir, tocilizumab, and convalescent plasma have been evaluated in low-quality observational studies, and it is not possible to determine the effectiveness and safety when ...
Evidencias COVID-19
Unidad de Evidencia y Deliberación para la Toma de Decisiones - Universidad de Antioquia
We found 19 new studies that met eligibility criteria, four systematic reviews, two clinical trials, and thirteen observational studies. In total, this rapid synthesis included 36 studies, two clinical practice guidelines, six systematic reviews, five clinical trials, and 23 observational studies. The evidence available on pharmacological treatments for the control of the infection COVID- 19 is yet limited and low quality
ver más ... 2020The use of low or moderate doses of glucocorticoids in patients with severe COVID-19 disease is suggested to reduce the possibility of progression of mild / moderate to severe disease and mortality.
Evidencias COVID-19
Unidad de Evidencia y Deliberación para la Toma de Decisiones - Universidad de Antioquia
We included 19 new studies that met eligibility criteria, four systematic reviews, two clinical trials, and 13 observational studies. In total, this rapid synthesis includes 36 studies, two clinical practice guidelines, six systematic reviews, five clinical trials, and 23 observational studies. The available evidence on pharmacological treatments for the control of COVID-19 infection is still limited and of low quality. Of these, two observational studies report beneficial effects of ...
ver más ... 2020The evidence on the effectiveness of chloroquine and hydroxychloroquine, besides being contradictory, is scarce and of low quality.
Evidencias COVID-19
Unidad de Evidencia y Deliberación para la Toma de Decisiones - Universidad de Antioquia
One clinical trial report that hydroxychloroquine decreases the clinical recovery time by 2 days, while another reports that there is no difference in viral clearance between patients receiving and not receiving the antimalarial drug. The included systematic reviews have conflicting conclusions, but all highlight the low quality of the evidence. An important precaution is that the combination of antimalarials with azithromycin, lopinavir/ritonavir and remdesivir, has been associated with an ...
ver más ... 2020The evidence on antiviral therapy with lopinavir / ritonavir, oseltamivir, and ganciclovir in seriously ill patients with COVID-19 is weak and contradictory, its effectiveness in reducing the risk of ...
Evidencias COVID-19
Unidad de Evidencia y Deliberación para la Toma de Decisiones. Universidad de Antioquía
Nineteen new studies meeting eligibility criteria, four systematic reviews, two clinical trials, and 13 observational studies were included. In total, this rapid synthesis includes 36 studies, two clinical practice guidelines, six systematic reviews, five clinical trials, and 23 observational studies. The available evidence on pharmacological treatments for the control of COVID-19 infection is still limited and of low quality.
ver más ... 2020