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NICE

NICE

NICE, in line with the WHO guideline, recommends not administering anti‑D prophylaxis to RhD‑negative individuals undergoing medical or surgical abortion up to 11+6 weeks’ gestation. The recommendation is based on the WHO systematic review and expert panel assessment, which identified very few relevant studies (all before 1975, with very low‑certainty evidence) and found no clinically significant benefit in preventing Rh alloimmunization at early gestational ages. The panel noted that ...

NICE

NICE

NICE recommends not to use falls risk prediction tools to estimate individual risk in older adults or in people aged 50 and over at higher risk, because available evidence is of very low quality and does not demonstrate sufficient predictive ability. These tools, used in hospitals, care homes, or community settings, show inadequate sensitivity and specificity and are often impractical to implement. Falls risk is multifactorial, depending on the interaction of individual factors (frailty, gait ...

NICE

NICE

NICE recommends not to routinely use balloon disimpaction of the baby’s head during emergency caesarean in the second stage of labour due to the lack of robust evidence showing clear benefit for the birthing person or the baby. The procedure should only be performed within formal research studies approved by an ethics committee and by staff trained in managing emergency caesarean deliveries with impacted fetal head. Evidence comes from a meta-analysis and experimental and observational ...

NICE

NICE

NICE recommends not to use aromatase inhibitors alone in people with ER-positive invasive breast cancer who have male reproductive organs (men, trans women, and non-binary people with testes). The recommendation is based on clinical evidence and physiological studies showing that, without testicular function suppression, aromatase inhibitors do not sufficiently reduce oestrogen levels to block tumour effects. The initial endocrine therapy of choice remains tamoxifen. If tamoxifen is not ...

NICE

NICE

NICE recommends not to routinely use alcohol-mediated perivascular renal sympathetic denervation in patients with resistant hypertension due to limited evidence on its long-term efficacy and safety. The procedure should only be performed within formal research studies approved by an ethics committee. The technique involves delivering dehydrated alcohol into the perivascular space of the renal arteries using a microneedle catheter, aiming to disrupt sympathetic nerve activity contributing to ...