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NICE

NICE

Treatment for untreated advanced renal cell carcinoma includes sunitinib, pazopanib, tivozanib or cabozantinib. Clinical trial evidence shows that, for people with untreated advanced renal cell carcinoma, avelumab plus axitinib increases how long people live without their disease getting worse compared with sunitinib. Early trial results suggest that avelumab plus axitinib also increases how long people with the disease live. But this is uncertain because the final trial results are not ...

NICE

NICE

Locally advanced or metastatic EGFR mutation-positive NSCLC is usually first treated with afatinib, erlotinib or gefitinib. Evidence from a randomised controlled trial suggests that people who take osimertinib live longer than people who take erlotinib or gefitinib. They also live longer before their disease gets worse. There is some uncertainty about the comparison of osimertinib with afatinib, which may be more effective than erlotinib and gefitinib, because there is no direct evidence ...

Evidencias COVID-19

Evidence aid

A variety of interventions have been applied to reduce the transmission of COVID-19 in healthcare personnel. The authors of this review included 7 studies, 5 of which were observational studies. All these suggest the following preventive measures in the protection of healthcare personnel: maintaining a safety distance, carrying out patient screening before consultations, use of hygienic measures such as hydro-alcoholic gel, use of appropriate masks and the practice of telemedicine. .

Essencial: Afegint valor a la pràctica clínica [Essencial: Adding value to the clinical practice]

Sociedad Catalana de Obstetricia y Ginecología

Vulvar synechiae are a very common acquired condition in which there is an adhesion between the labia minora of the vulva that partially or totally closes the introitus, and does not allow a complete view of the entrance to the vagina or, sometimes, to the urethral meatus. The vast majority are asymptomatic and resolve spontaneously, without treatment, during puberty or before reaching it. The literature is of low or very low quality and therefore the recommendations are mainly by ...

Essencial: Afegint valor a la pràctica clínica [Essencial: Adding value to the clinical practice]

Sociedad Catalana de Obstetricia y Ginecología

Preeclampsia can affect 5-10% of pregnancies. Currently the definition of pre-eclampsia is established as arterial hypertension ≥ 140/90 (de novo after 20 weeks of gestation) and with at least ≥ 1 of the following criteria: proteinuria and / or maternal target organ damage (liver, renal, neurological or hematological) and / or utero-placental dysfunction. The clinical practice guidelines that have evaluated the prescription of absolute bed rest to preeclamptic women without serious ...