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NICE

NICE

After 3 lines of treatment, people usually have pomalidomide plus dexamethasone, or daratumumab alone.Clinical trial evidence suggests that Isatuximab plus pomalidomide and dexamethasone delays the disease progressing and increases how long people live compared with pomalidomide plus dexamethasone. But, the trial is not finished so the benefit in the longer term is uncertain.

NICE

NICE

Galcanezumab is 'indicated for the prophylaxis of migraine in adults who have at least 4 migraine days per month'. Treatment options for preventing episodic or chronic migraine include beta-blockers, antidepressants and anticonvulsant drugs. If episodic migraine does not respond to at least 3 oral preventive drug treatments, best supportive care (treatment for the migraine symptoms) is offered. If chronic migraine does not respond to at least 3 oral preventive drug treatments, botulinum toxin ...

NICE

NICE

Lynch syndrome is an inherited condition that increases the risk of certain types of cancer, including endometrial and colorectal cancer. If diagnosed, treatment and surveillance can be offered to reduce the risk of having another Lynch syndrome-associated cancer (in particular colorectal cancer) or identify it earlier. The external assessment group did a systematic review to identify evidence on the clinical effectiveness and diagnostic accuracy of immunohistochemistry and microsatellite ...

NICE

NICE

PIPAC is a minimally invasive procedure that is performed by administering chemotherapy in the form of an aerosol into the peritoneal cavity. To do this, a special device is used that generates the aerosol and a microinjection pump or laparoscopic nebulizer connected to a standard double-head high-pressure injector through which the cytostatic drugs will be injected. Peritoneal Carcinomatosis is the tumor dissemination that affects, in a localized or massive way, the serosa of the peritoneum ...

NICE

NICE

Squamous cells in the oesophagus may become dysplastic (squamous dysplasia). In some people, this condition may become malignant. Current management includes lifestyle change, acid-suppressing medicines, endoscopic mucosal resection, endoscopic submucosal dissection, ablative therapies and surgery. Ablative therapies include radiofrequency ablation, photodynamic therapy, argon plasma coagulation, laser ablation, multipolar electrocoagulation and cryotherapy. The evidence is not very high as ...