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Non-invasive tests for Helicobacter pylori (urea breath test, stool antigen, serology) are not recommended for initial diagnosis in pediatric patients. H. pylori infection in children seldom causes significant clinical disease, and testing does not improve symptoms in those without alarm features. Diagnostic confirmation should be limited to children undergoing endoscopy due to specific clinical indications, using invasive methods with culture and antibiotic susceptibility testing. ...
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Deliberately delaying the introduction of potentially allergenic foods during complementary feeding in infants does not prevent allergies and may in fact increase their risk. Robust evidence shows that early introduction of foods such as peanuts, eggs, wheat, and cow's milk reduces the likelihood of IgE-mediated food allergies, even in infants with a family history of allergy or atopic conditions. Early exposure promotes immune tolerance, particularly when introduced during the first year of ...
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Serum vitamin D (25-hydroxyvitamin D or calcidiol) testing is not recommended in asymptomatic adults without risk factors for deficiency. There is no supporting evidence for its clinical utility in the general population, and no demonstrated benefits for musculoskeletal or other health outcomes. Furthermore, uncertainty remains regarding the threshold at which vitamin D deficiency becomes clinically significant. Testing should be reserved for individuals with clinical suspicion of deficiency or ...
Community-acquired pneumonia (CAP) is one of the leading causes of hospitalization and mortality from infections in adults. However, in more than 50% of cases, no causative pathogen is identified. Urinary antigen tests (UATs) for Streptococcus pneumoniae and Legionella pneumophila have been used to facilitate rapid diagnosis of these pathogens, with the expectation of improving antibiotic treatment and reducing hospitalization duration.
UATs have potential advantages, such as rapid turnaround ...
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Repeating previously performed genetic tests—such as those for hereditary thrombophilia (R506Q, G20210A), type 1 hemochromatosis (C282Y, H63D), or DQ2/DQ8 haplotypes for celiac disease—offers no clinical benefit and represents an unnecessary expenditure of healthcare resources. Effective demand management in laboratory medicine should prevent redundant testing and promote rational use of diagnostics, especially in genetics, where results are stable over time. Automated systems that reject ...