WHO recommendations on antenatal care for a positive pregnancy experience
(Context-specific recommendation)
Remarks
• This recommendation is consistent with the WHO Guideline: preventive chemotherapy to control soiltransmitted
helminth infections in high-risk groups (140), which states that:
“Preventive chemotherapy (deworming), using single-dose albendazole (400 mg) or
mebendazole (500 mg) is recommended as a public health intervention for pregnant women,
after the first trimester, living in areas where both: (1) the baseline prevalence of hookworm
and/or T. ...
WHO recommendations on antenatal care for a positive pregnancy experience
(Context-specific recommendation – research)
Remarks
• This context-specific recommendation relates to anti-D prophylaxis during pregnancy and not the practice of giving anti-D after childbirth, for which there is high-certainty evidence of its effect of reducing RhD alloimmunization in subsequent pregnancies (129). Anti-D should still be given postnatally when indicated.
• Determining the prevalence of RhD alloimmunization and associated poor outcomes among women in LMIC settings, as ...
WHO recommendations on antenatal care for a positive pregnancy experience
(Context-specific recommendation – research)
Remarks
• Further research is needed to determine the best strategies for preventing RUTI in pregnancy, including the effects of antibiotic prophylaxis on pregnancy-related outcomes and changes in antimicrobial resistance.
WHO recommendations on antenatal care for a positive pregnancy experience
Recommended
Remarks
• This recommendation should be considered alongside the recommendation on ASB diagnosis.
• Stakeholders may wish to consider context-specific ASB screening and treatment based on ASB and preterm birth prevalence, as it may not be appropriate in settings with low prevalence.
• Evidence on preterm birth is of low certainty and large multicentre trials are needed to confirm whether screening and antibiotic treatment reduces preterm birth and perinatal mortality in ...
WHO recommendations on antenatal care for a positive pregnancy experience
(Not recommended)
Remarks
• The GDG noted that the evidence base for the use of Doppler ultrasound of fetal blood vessels in high risk pregnancy is already established.
• The GDG agreed that the value of a single Doppler ultrasound examination of fetal blood vessels for all pregnant women in the third trimester needs rigorous evaluation, particularly in LMIC settings. Future trials should be designed to evaluate the effect of a single Doppler ultrasound on preventable perinatal deaths.