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Prescrire bilan. Towards better patient care: drugs to avoid

Prescrire International

Olmesartan can cause sprue-like enteropathy leading to chronic diarrhoea (potentially severe) and weight loss, and, possibly, an increased risk of cardiovascular mortality. It is better to choose losartan or valsartan.

Prescrire bilan. Towards better patient care: drugs to avoid

Prescrire International

Nicorandil can cause severe mucocutaneous ulceration. A nitrate is a better option to prevent angina attacks.

Prescrire bilan. Towards better patient care: drugs to avoid

Prescrire International

Ivabradine can cause visual disturbances, cardiovascular disorders (including myocardial infarction), potentially severe bradycardia and other cardiac arrhythmias. It has no advantages over other available options in either angina or heart failure.

Prescrire bilan. Towards better patient care: drugs to avoid

Prescrire International

Dronedarone is less effective than amiodarone, yet has at least as many severe adverse effects, in particular hepatic, pulmonary and cardiac disorders. Amiodarone is a better option.

Prescrire bilan. Towards better patient care: drugs to avoid

Prescrire International

Bezafibrate, ciprofibrate and fenofibrate have numerous adverse effects, including cutaneous, haematological and renal disorders. When a fibrate is justified, gemfibrozil is the only one that has been shown to prevent the cardiovascular complications of hypercholesterolaemia.