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Prescrire bilan. Towards better patient care: drugs to avoid

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It frequently provoke eye pain and irritation, have immunosuppressive effects and may cause ocular or periocular cancer, yet have no proven efficacy. It is better to use artificial tears for example for symptomatic relief, several types of which are available.

Prescrire bilan. Towards better patient care: drugs to avoid

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Vinflunine increases median survival by two months at best compared with symptomatic treatment. There is a high risk of haematological adverse effects (including aplastic anaemia), and a risk of serious infections and cardiovascular disorders (torsades de pointes, myocardial infarction, ischaemic heart disease), sometimes resulting in death.

Prescrire bilan. Towards better patient care: drugs to avoid

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Serious adverse effects (diarrhoea, pneumonia, hypertension) occur in about one-third of patients. There is also a risk of interstitial lung disease, torsades de pointes and sudden death.

Prescrire bilan. Towards better patient care: drugs to avoid

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It showed no tangible efficacy in comparative trials in ovarian cancer or soft-tissue sarcomas but has very frequent and severe gastrointestinal, haematological, hepatic and muscular adverse effects. It is unreasonable to add trabectedin to platinum-based chemotherapy for ovarian cancer. When chemotherapy is ineffective in patients with soft-tissue sarcomas, it is best to focus on symptomatic treatments, to limit the clinical consequences of the disease.

Prescrire bilan. Towards better patient care: drugs to avoid

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It has not been shown to prolong survival in refractory or relapsed multiple myeloma. It provokes many, often serious, adverse effects that affect many vital functions, hastening the death of many patients.