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Prescrire bilan. Towards better patient care: drugs to avoid

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It expose patients to a higher incidence of QT prolongation and torsades de pointes than other SSRIs and worse outcomes in the event of overdose.

Prescrire bilan. Towards better patient care: drugs to avoid

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It expose patients to a higher incidence of QT prolongation and torsades de pointes than other SSRIs and worse outcomes in the event of overdose.

Prescrire bilan. Towards better patient care: drugs to avoid

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It not only has the adverse effects of the so-called “selective” serotonin reuptake inhibitors (SSRIs) but also carries a risk of cardiac disorders (hypertension, tachycardia, arrhythmias) due to its noradrenergic activity. Duloxetine can also cause hepatitis and severe cutaneous hypersensitivity reactions such as Stevens-Johnson syndrome.

Prescrire bilan. Towards better patient care: drugs to avoid

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It has no proven efficacy beyond the placebo effect, but can cause hepatitis and pancreatitis, suicide and aggressive outbursts, as well as serious skin disorders including Stevens-Johnson syndrome.

Prescrire bilan. Towards better patient care: drugs to avoid

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It carries a risk of adverse effects including hepatic disorder.