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Lanadelumab is recommended as an option for preventing recurrent attacks of hereditary angioedema in people aged 12 and older,
NICE
National Institute for Health and Clinical Excellence (NICE)
It is recommended only if: they are eligible for preventive C1-esterase inhibitor (C1-INH) treatment in line with NHS England's commissioning policy, that is, they are having 2 or more clinically significant attacks (as defined in the policy) per week over 8 weeks despite oral preventive therapy, or oral therapy is contraindicated or not tolerated the lowest dosing frequency of lanadelumab is used in line with the summary of product characteristics, that is, when the condition is in a stable, ...
ver más ... 2019Refer urgently all children aged under 4 years with headache for neurological assessment.
NICE
National Institute for Health and Clinical Excellence (NICE)
The committee agreed that headache in a child aged under 4 years is an unusual symptom and, when present, has a high chance of being associated with a significant intracranial disease. Because the child is unable to articulate clearly what is wrong, parents may report excessive crying, a high-pitched cry or excessive irritability.
ver más ... 2019In children with dizziness, examine the ears for any signs of infection, inflammation or eardrum perforation.
NICE
National Institute for Health and Clinical Excellence (NICE)
The committee agreed that middle ear infection and middle ear effusion can be a cause of dizziness in children. They noted that the child may have fever, pain and diminished hearing, or a recent history of these, and that the eardrum might appear red and inflamed or bulging.
ver más ... 2019For children who have blackouts, seizures or amnesia for events after a head injury, follow the recommendations on pre-hospital assessment, advice and referral to hospital in the NICE guideline on ...
NICE
National Institute for Health and Clinical Excellence (NICE)
Transient loss of consciousness after a head injury in children is usually immediate or within a few minutes. Much-delayed paroxysmal events after head injury in children – days or weeks later – are rare but warrant urgent referral for neurological assessment. The committee considered that the recommendations on pre-hospital assessment, advice and referral to hospital in the NICE guideline on head injury should be followed.
ver más ... 2019Do not routinely refer children aged over 12 years with blackouts if there are clear features of vasovagal syncope, even if associated with brief jerking of the limbs, in line with recommendation ...
NICE
National Institute for Health and Clinical Excellence (NICE)
Vasovagal syncope is common in young people, and is often inappropriately referred because of concern that it represents seizures. The committee considered that the recommendation on vasovagal syncope in the NICE guideline on transient loss of consciousness ('blackouts') in over 16s is applicable to children aged 12 to 15 years.
ver más ... 2019