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Evidencias COVID-19

Centro Cochrane Iberoamericano

This study highlights that one of the main routes of transmission of SARS-CoV-2, which is high, is produced by the emission of small respiratory drops when coughing or sneezing, although data on transmission when speaking is also available. Therefore, potential contagion situations multiply. Transmission occurs at any stage of infection (both in an initial phase, in asymptomatic people, and in those with symptoms) and some studies show that infected people have a high transmission capacity in ...

Evidencias COVID-19

Oxford COVID-19 Evidence Service.

There are no published trials of prophylaxis. Two trials of hydroxychloroquine treatment that are in the public domain, one non-peer reviewed, are premature analyses of trials whose conduct in both cases diverged from the published skeleton protocols registered on clinical trial sites. Neither they, nor three other negative trials that have since appeared, support the view that hydroxychloroquine is effective in the management of even mild COVID-19 disease.

Evidencias COVID-19

Hospital Universitario Donostia – Unidad de Epidemiología Clínica

From the analysis of two articles found related to the topic (a systematic review and a randomized clinical trial), it highlights: - A systematic review, where the search strategy is not described, the quality evaluation and no meta-analysis is considered, addresses vitamins A, B, C, D, E, Omega-3 PUFA, Selenium, Zinc and Iron, in addition to other treatments (immunoglobulins, etc). However, they do not describe or find experimental studies (RCTs) evaluating the efficacy of these hypothetical ...

Evidencias COVID-19

Hospital Universitario Donostia – Unidad de Epidemiología Clínica

Different drugs have been proposed for cytokine storm management: • Inhibit IL-1, with Anakinra • Inhibit IL-6 by Tocilizumab • Anti-inflammatories like Celecoxib and Mesalazine (+ neuraminidase inhibitors) • Gemfibrocil, which inhibits IL-6, gamma-Interferon and TNF • Corticosteroids • Intravenous immunoglobulin None of them shows conclusive evidence for viral diseases that are accompanied by a cytokine storm. The basis for treatment is purely pathophysiological.

Evidencias COVID-19

Hospital Universitario Donostia – Unidad de Epidemiología Clínica

Scientific basis: 1. Several studies that I could not access (n = 15) in vitro with COVID-19 show efficacy, without specifying the magnitude. 2. It showed in vitro efficacy against other coronaviruses. (Virology Journal 2005; 2:69) 3. Multicenter clinical trial 10 Chinese hospitals (n = 100), original source inaccessible, 500 mg / day, they say that it shows clinical efficacy in clarifying the viral load and improvement of lung lesions. (BioScience Trends. 2020; 14 (1): 72-73. doi: 10.5582 / ...