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Data show no evidence that hydroxychloroquine has efficacy against covid-19
Prescrire bilan. Towards better patient care: drugs to avoid
Prescrire.org
The results of a new randomised comparative but non-blinded trial of high-dose hydroxychloroquine versus standard care in 150 patients hospitalised for covid-19 have been published. The only notable difference between the groups was the high incidence of adverse effects in the group treated with hydroxychloroquine. The results of other studies (non-randomised and providing only low-quality evidence) show no evidence that hydroxychloroquine has efficacy against covid-19. The hypothesis that ...
ver más ... 2020There is no evidence that the combination of hydroxychloroquine with azithromycin has clinical efficacy as a treatment for patients with covid-19, and an increased risk of serious cardiac arrhythmias ...
Prescrire bilan. Towards better patient care: drugs to avoid
Prescrire.org
Given the adverse effect profiles of hydroxychloroquine and azithromycin, an increased risk of serious cardiac arrhythmias is predictable with this combination; it is being confirmed by more and more clinical data. A team in New York studied electrocardiographic data from a series of 84 patients who were hospitalised with covid-19 and treated with the hydroxychloroquine + azithromycin combination. During treatment, prolongation of the ECG QT interval exceeding 500 milliseconds was observed in ...
ver más ... 2020Standard surgical masks are as effective as respirator masks (e.g. N95, FFP2, FFP3) for preventing infection of healthcare workers in outbreaks of viral respiratory illnesses such as influenza. No ...
Evidencias COVID-19
Oxford COVID-19 Evidence Service.
Both types of mask need to be used in combination with other PPE measures. Respirator masks are recommended for protection during aerosol generating procedures (AGPs). Trials comparing different kinds of mask have been summarised in a recent high-quality systematic review and provide cautious support for the use of standard surgical masks in non AGPs, though the empirical studies underpinning this conclusion were not in a COVID-19 population, and only one was in a community setting. It is ...
ver más ... 2020Exposure simulation studies suggest that the risk of exposure in healthcare workers is greater with aprons than with gowns but do not provide sufficient data to quantify those risks in the context of ...
Evidencias COVID-19
Oxford COVID-19 Evidence Service.
This review found no relevant trials comparing the effectiveness of gowns against aprons. The WHO recommends long-sleeved non-sterile gowns and gloves for both aerosol-generating procedures (AGPs) and non-AGPs. The US CDC has suggested using aprons over gowns as an additional measure to provide protection from contamination of garments during aerosol generating procedures. Properly used protective clothing is only one component of a package of personal protective measures (which also includes ...
ver más ... 2020The recommendations from current guidelines overall seem to support environmental measures for infection prevention and antiviral chemoprophylaxis for infection management as the most appropriate ...
Evidencias COVID-19
Oxford COVID-19 Evidence Service.
The most commonly recommended prevention strategies across the clinical practice guidelines were hand hygiene, wearing personal protective equipment, social distancing/isolation, disinfecting surfaces, droplet precautions, surveillance and evaluation, conducting diagnostic testing to confirm suspected respiratory illness, policies and procedures for visitors, policies, and procedures for staff, and respiratory hygiene/cough etiquette For managing respiratory illness in long-term care ...
ver más ... 2020