Coronavirus (COVID-19): Evidence Collection. Evidence Aid
Like COVID-19, severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS) are acute respiratory diseases caused by a coronavirus. Antiviral therapy with Lopinave/Litonawe (LPV/r) was used to treat patients with these earlier coronaviruses and might be considered as a treatment for COVID-19.
In this rapid systematic review, the authors searched Chinese and English literature databases for research of any design that compared LPV/r versus either placebo or standard ...
Coronavirus (COVID-19): Evidence Collection. Evidence Aid
Sepsis and septic shock are life-threatening complications of infection. Fluid therapy, either conservative or liberal, is used during its initial treatment. This may have relevance for the treatment of some critically ill patients with COVID-19.
Liberal fluid therapy carried a greater risk of death in children with sepsis and septic shock, and there was insufficient evidence to conclude that it had any beneficial effects on other outcomes, compared to conservative fluid therapy.
The effects of ...
Coronavirus (COVID-19): Evidence Collection. Evidence Aid
A variety of interventions are likely to be used to limit the impact of the COVID-19 pandemic. Evidence on interventions that were used to reduce pandemic influenza transmission and infection may help in developing strategies for the management of COVID-19.
Wearing a facemask in conjunction with hand hygiene reduces infection compared to hand hygiene alone during an influenza pandemic.
School closure reduced contacts with infected people during an influenza pandemic.
Coronavirus (COVID-19): Evidence Collection. Evidence Aid
A variety of interventions are likely to be used to limit the impact of the COVID-19 pandemic. Evidence on interventions that were used to reduce pandemic influenza transmission and infection may help in developing strategies for the management of COVID-19.
The effects of many non-pharmacological interventions (including border control measures) are uncertain during an influenza pandemic, due to a lack of high quality evidence.
There is insufficient evidence to determine the effects of ...
Coronavirus (COVID-19): Evidence Collection. Evidence Aid
Some patients with COVID-19 will become critically ill and need treatment in an intensive care unit (ICU). One potential complication of this is the development of delirium, which has been associated with longer stays in ICU or hospital, greater risk of early death and long-term cognitive impairment. Various interventions have been tested to try to prevent delirium in patients in ICU.
The effects of many pharmacological and non-pharmacological interventions used to try to prevent delirium in ...