In this sistematic review, the authors searched for studies on the effects of nanoscale materials against coronaviruses in vitro or in animal models. They included 6 in vitro studies, 14 animal model studies and 1 that was both an in vitro and animal model study. Positive association was found between efficacy of nanoscale materials and coronaviruses in vitro and in animal models.
There is no evidence that the use of favipiravir in the treatment of patients hospitalized for moderate forms of COVID-19 increases clinical and radiological improvement and viral clearance. Due to its relative safety, it would be an alternative treatment for patients without risk factors with moderate forms.
We are very uncertain as to whether a higher or lower oxygen target is more beneficial in patients with ARDS and receiving mechanical ventilation in an intensive care setting. We identified only one RCT with a total of 205 participants exploring this question, and rated the risk of bias as high and the certainty of the findings as very low. Further well‐conducted studies are urgently needed to increase the certainty of the findings reported here. This review should be updated when more ...
Current recommendations for safe physical distancing (one to two meters) are based on outdated evidence. In a systematic review carried out in the context of the COVID-19 pandemic, it was observed that the distribution of viral particles is affected by numerous factors such as air flow, ventilation, type of activity, viral load and duration of The exhibition. In higher risk situations, a physical distance of more than two meters should be considered and occupation time minimized. Physical ...
Cochrane Portugal - Institute for Evidenced Based Health
The systematic review includes 22 studies of moderate quality, with a high risk of bias in 50% of the studies. It is concluded that there is no evidence that rapid diagnosis techniques for SARS-CoV-2 infection in primary or hospital care, which include screening tests and confirmatory studies of infection (by RT-PCR and clinical picture) have the same precision as in specialized laboratories.