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The use of pentoxyverine for cough is not recommended
Prescrire bilan. Towards better patient care: drugs to avoid
Prescrire International
Pentoxyverine, a centrally-acting cough suppressant, can cause cardiac disorders including QT prolongation, and serious allergic reactions
ver más ... 2020Early treatment with IFNα 2b has been associated with a reduction in hospital mortality among COVID-19 patients from severe to critical.
Evidencias COVID-19
IHCAI – DIME. Información seleccionada sobre intervenciones para el tratamiento de COVID-19
A retrospective cohort study was conducted with data from medical centers in China. 29.4% of the total confirmed COVID-19 cases in two cities were studied. Acute inflammation, often seen in critically ill patients with COVID-19, was reported to be the result of type I IFN expression and the subsequent unbalanced IFN response with excessive cytokine production, which could be corrected by IFN administration therapeutic. It is therefore plausible that early administration of IFN in COVID-19 ...
ver más ... 2020The use of Ginko biloba is not recommended for cognitive impairment in elderly patients.
Prescrire bilan. Towards better patient care: drugs to avoid
Prescrire International
Ginkgo biloba, used in cognitive impairment in elderly patients, has no proven efficacy beyond that of a placebo, but can cause haemorrhage, gastrointestinal disorders, skin disorders, seizures and hypersensitivity reactions.
ver más ... 2020The antiviral efficacy of the antineoplastic agent Plitidepsin (PTD) has not been demonstrated for the treatment of COVID-19.
Evidencias COVID-19
IHCAI – DIME. Información seleccionada sobre intervenciones para el tratamiento de COVID-19
Plitidepsin (PTD) is an antineoplastic drug licensed in Australia for the treatment of relapsed or refractory multiple myeloma. It does not have a marketing authorization from the European Medicines Agency. The laboratory responsible for its commercialization ensures that PTD has shown antiviral activity in a human hepatoma cell line infected with the HCoV-229E-GFP virus, a virus similar to SARS-CoV-2. At the moment there is no evidence to make it effective for the treatment of COVID-19 and the ...
ver más ... 2020There is uncertainty about the use of antimicrobial mouthwashes and nasal sprays used by healthcare workers to protect themselves when treating patients with suspected or confirmed COVID-19 infection.
Evidencias COVID-19
Cochrane - Revisión rápida
There is currently no evidence of the benefits and risks of healthcare workers using antimicrobial mouthwashes or nasal sprays to protect themselves when treating people with COVID-19. No completed studies were found for inclusion in this review. Three ongoing studies (including two RCTs) were identified, claiming to include almost 700 participants. The interventions included in these trials are povidone iodine, nitric oxide and GLS-1200 oral spray. Once these studies are completed, their ...
ver más ... 2020