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Choosing Wisely Canada

Burns Canada

Albumin infusions are part of the acute resuscitation strategy of many burn centres globally, and may be associated with the administration of smaller volumes of crystalloid. Patients with severe burn injuries frequently develop chronic hypoalbuminaemia following resuscitation, due to hypermetabolism, fluid and protein loss from wounds, and impaired albumin synthesis. Attempting to restore serum albumin levels with the continuous infusion of human albumin solutions does not appear to improve ...

Evidencias COVID-19

Evidence Aid

Squama Manitis (pangolin scale) is used in traditional Chinese medicine but its effectiveness for the treatment of COVID-19 patients is not known. In this rapid review, the authors searched for studies of the therapeutic use of Squama Manitis for any health condition. They restricted their searches to articles published before 1 May 2020. They included 4 randomized trials, 1 case control study, 3 case series and 7 case reports. There were no included studies of the use of Squama Manitis for ...

Evidencias COVID-19

Evidence Aid

The COVID-19 pandemic is placing a great strain on healthcare systems and increasing use is being made of telehealth. This is a rapid review. The studies address the use of telemedicine for the treatment of outpatients with urogynecological conditions during the COVID-19 pandemic. At the time of this review, the included studies showed that virtual visits are effective for established Female Pelvic Medicine and Reconstructive Surgery patients who do not require a physical examination or for ...

NICE

NICE

Standard care for an acute episode of acquired thrombotic trombocytopenic purpura includes plasma exchange and immunosuppressant medicines.Adding caplacizumab likely reduces the long-term complications of acquired thrombotic trombocytopenic purpura and risk of death around the time of an acute episode, but it is unclear by how much. This is because the trial results do not address whether adding caplacizumab improves either length or quality of life in the long term after people stop taking the ...

NICE

NICE

The clinical trials show that for moderate to severe active rheumatoid arthritis that has not responded adequately to conventional DMARDs, upadacitinib with methotrexate is more effective than adalimumab with methotrexate or placebo with methotrexate. Based on the health-related benefits and costs compared with conventional and biological DMARDs, upadacitinib alone, or with methotrexate, is recommended only for severe active rheumatoid arthritis.