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Cobimetinib in combination with vemurafenib is not recommended within its marketing authorisation for treating unresectable or metastatic melanoma in adults with a BRAF V600 mutation.
NICE
National Institute for Health and Clinical Excellence (NICE)
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ver más ... 2016Necitumumab, in combination with gemcitabine and cisplatin, is not recommended within its marketing authorisation for adults with locally advanced or metastatic epidermal growth factor receptor ...
NICE
National Institute for Health and Clinical Excellence (NICE)
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ver más ... 2016Ramucirumab, in combination with docetaxel, is not recommended within its marketing authorisation for treating locally advanced or metastatic non-small-cell lung cancer in adults whose disease has ...
NICE
National Institute for Health and Clinical Excellence (NICE)
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ver más ... 2016Don’t recommend carpal tunnel release without electrodiagnostic studies to confirm the diagnosis and severity of nerve entrapment.
Choosing Wisely Canada
Canadian Association of Physical Medicine and Rehabilitation
Carpal tunnel release is a highly effective treatment for Carpal Tunnel Syndrome. Clinicians considering referral for surgical management should be aware that good surgical outcome is best correlated with a combination of positive clinical and positive electrodiagnostic studies (EDX). Clinical tests together with EDX have a better association with surgical outcome than either alone. Pre-op nerve conduction study severity can also better predict time to resolution and degree of resolution of ...
ver más ... 2016Don’t use benzodiazepines for the treatment of agitation in the acute phase of traumatic brain injury after initial stabilization.
Choosing Wisely Canada
Canadian Association of Physical Medicine and Rehabilitation
After initial stabilization and when intracranial pressure is controlled, the use of benzodiazepines in the acute phase of traumatic brain injury should be limited to specific medical indications, such as alcohol withdrawal. In animal models of acute TBI, benzodiazepines have been associated with slowed or halted recovery. Moreover, benzodiazepines have adverse effects on cognition, and can cause respiratory depression, paradoxical agitation, and anterograde amnesia. Non-pharmacologic ...
ver más ... 2016