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Upadhayay et al.

Evaluation for medical abortion eligibility usually includes an ultrasound or pelvic exam. To reduce physical contact during the COVID-19 pandemic, many doctors stopped ordering tests before medical abortion and instead examined patients for length of pregnancy and risk of ectopic pregnancy based on medical history alone. . However, few studies have been conducted on the outcomes and safety of this new model of care. The aim of the study was to evaluate the outcomes and safety of a chart-based ...

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Park et al.

Gabapentin has been increasingly used as part of a multimodal analgesia regimen to reduce the use of opioids in the management of perioperative pain. However, the safety of perioperative use of gabapentin among older patients remains uncertain. This study examines in-hospital adverse clinical events associated with the perioperative use of gabapentin among older patients undergoing major surgery. It is a retrospective cohort study that included patients 65 years of age or older who underwent ...

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Breeden et al.

Demand for citrate products increased in early 2021 due to a significant increase in the use of this material as a result of increasing COVID-19 infection rates and its use in COVID-19 development of vaccines and therapies. This caused a shortage of 3.2% sodium citrate laboratory tubes used primarily for testing prothrombin time (PT), international normalized ratio (INR), and partial thromboplastin time (PTT) test. The study followed the SQUIRE reporting guideline. The study was carried out ...

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Chen et al.

Recent guidelines recommend a systolic blood pressure goal of less than 150mmHg or even 130mmHg for adults aged 60 years or older. However, harms from intensive blood pressure treatments occur immediately (eg, syncope, fall), and benefits for cardiovascular event reduction emerge over time. Therefore, the benefit-risk of intensive blood pressure treatment should be clearer, particularly for those patients with a limited life expectancy. The evidence comes from the analysis of 6 randomized ...

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McDonald et al.

Deprescribing is the gradual reduction or supervised cessation of medications that are no longer needed or beneficial. In acute hospitalizations, adverse drug events are common and up to 60% are considered preventable. Scalable deprescribing interventions can reduce polypharmacy and potentially inappropriate medication use; however, few studies have been large enough to assess the impact that deprescribing may have on adverse drug events. In this randomized clinical trial in hospitalized ...